![]() The study subjects were six beagle dogs (age, 2-5 years weight, 8-12 kg), all of which comprised the experimental group (this was an exploratory study). This experimental study was approved by the Experimental Ethics Committee of the Xi'an Jiaotong University (Permit number: 2017-773). The research protocol and all experimental procedures were strictly in accordance with the Guidelines for the Care and Use of Experimental Animals issued by the Xi'an Jiaotong University Medical Center. Therefore, we designed a TEF repair device based on the magnetic compression technique and verified the safety and feasibility of repairing TEF using this device through experiments. At present, the magnetic compression technique has been applied in digestive tract reconstruction 8, vascular anastomosis 9, and urinary system reconstruction 10. A smooth anastomosis can be formed by pressing the body tissue, and the operation is simpler than traditional manual anastomosis. Magnetic compression technique, which is a new anastomosis technology, uses the non-contact force of mutual attraction between magnets to solve various clinical problems 8. Although traditional surgical resection can have a curative effect on resectable TEF, the operation is complicated and time-consuming 4. Surgical resection includes cervicotomy, thoracotomy, and thoracoscopy 5, 6, 7. However, endoscopic clipping and stent implantation do not completely cure the condition and are prone to slippage they may even cause enlargement and recurrence of the fistula 3, 4. Current treatments for TEF include endoscopic clipping, patch repair, stent implantation, and surgical resection. Although the incidence of TEF is not high, it has a high mortality rate. TEF develops in 5–15% of patients with esophageal cancer 2. Congenital TEF mostly accompanies esophageal atresia, which occurs in 1/3000–5000 births, and only 4% of congenital TEF cases show an isolated H-type fistula (i.e., TEF without esophageal atresia) 1. It can be caused by congenital malformation, tumors, surgery, and trauma, among other causes. Tracheoesophageal fistula (TEF) is a pathological passage formed between the trachea and esophagus. Magnetic compression technique can be effectively used to repair tracheoesophageal fistula, shorten the operation time, and simplify the operation procedure, and thus, it has the potential for clinical application. Histological observation showed that the anastomosis was slightly inflamed, the mucosal layer and surrounding tissues were arranged neatly, and the structure was slightly disordered. In all dogs, after specimen collection, it was observed that the fistula was successfully closed and the mucosal layer was smooth and flat. One dog had a postoperative wound infection, and the rest had no postoperative complications. The average intraoperative blood loss was less than 10 mL. The average operation time was 23.67 ± 4.50 min. The tracheoesophageal fistula repair operation was successfully completed for all six beagles. Samples were obtained 14 days after the operation, and fistula repair was observed. The operation time, intraoperative blood loss, postoperative complications, and wound healing were monitored. After the tracheal and esophageal spaces were freed during the operation, two magnets were used to clamp the fistula. Six beagle dogs underwent surgical repair after constructing a tracheoesophageal fistula model. The purpose of this study was to verify its feasibility in an animal experiment. Based on the magnetic compression technique, we designed a novel method for the treatment of tracheoesophageal fistula. There are various surgical methods for tracheoesophageal fistula however, there is presently no unified standard.
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